The rise of bigger and more powerful European nations led to the downfall of Venice. Political developments in the mainland states and emergence of Ottoman Empire posed major threat to Venice as it drained Venice financially; in order to build up its military and defense against these threats.
For example, from around the 13th century, the Ottoman Empire began expanding its influence from the Middle East into Europe. Ottoman had replaced Genoa as Venice's greatest competitor for maritime control. The Venetians could not face the large Ottoman armies on their own and their involvement in mainland had drained a large part of the city-state's energy and resources. Venice, as a result, was forced to give some of its less important territories to avoid further losses.
Venetians had to fight hard to maintain control of Adriatic Sea. The Ottoman had acquired territories along coast of Adriatic Sea and launched attacks at Venetians territories from here. Venice had to resort to galleys to fight off attack which disrupt its trading purposes.
The Ottoman Empire also stated sea campaigns and fought a seven-war with the Venetians for control of the Aegean Sea and Adriatic Sea. These had drained Venice's resources and manpower and disrupted trade. Venice had to contain the power of the Ottoman and had to strike a balance of power with the Ottoman and European neighbors at the same time. Their actions caused European neighbors to develop a deep postulation for Venice.
The Ottoman Empire had caused threats to Venice via sea and land competitions in areas such as trade. Venice had lost trade competition to Ottoman Empire and affected Venice negatively. This eventually led to the fall of Venice.
Another one competition that Venice faced is the league of Cambria. Venice's growing influence in the region made it unpopular among the various mainland states. Some larger states felt theta Venice was gaining too much power and control over northern Italy and wanted to recapture Dentition territories.
Therefore' the European countries set up a military alliance in 1508 known as the league of Cambria which consisted of most major powers in Europe. It aimed to reduce the power of Venice and divide its territories amongst the larger states. In one of the battle, Agnadello, the Venetian mercenary army was badly defeated, and many of its territories fell to members of the League.
Due to that, Venice's political and military capabilities is seeing weakened. In an attempt to negotiate for peace, it also results in the losing of states by gaining concession in terms of territories. The lost of wars also drained and weekend Venice's resources. Venice had to raise taxes to finance the employment of its mercenary armies to replenish its military power.
This lead to weakening of political stability in the Venice state as well. As nobles were forced to give up their pay in order to finance the military, this caused unrest and disorder to the state, which contributed to internal strife and fall of Venice ultimately.
