A man known as Belisarus in 536 led an army of the eastern empire and surrounded Rome. His plan was to surround Rome until it submits due to hunger. In other to achieve their aim, there cut off the food and water supply of Rome. One mistake there made was to dig their entrenchment near campagna. When summer came, malaria struck their camp, even belisarus barely escaped with his life even after been struck with malaria.
In 964, it was known that an emperor known as Otto attacked Rome, but he lost all his men to malaria and even the ones that survived prayed to see the next day. One of his painful losses was that he lost his own son to malaria even after medical intervention.
It seems to say malaria goes way back to the history of the Roman Empire itself because other people that tried to attack Rome and failed are people like Frederick 1 called Barbarossaa and Henry IV.
Alexander the great failed on his attempt to subjugate the world because he had fever. This was the top of his dreams but malaria won't let it happen.
Cesare Borgia the son of Pope Alexander VI tried to dominate all of Italy when his father died in 1503. But he soon contracted fever but before he could recover with the help of his family doctor, the opportunity had passed.
During the revolutionary, malaria continued to spread throughout America. It was believed that it was malaria that made the British to surrender at Yorktown
Napoleon Bonaparte was prevented from stopping the uprising in Hati in 1801 because of malaria and yellow fever
Malaria was the weapon Napoleon used against the English in 1809. he did this by flooding their camp in other to provide a breeding ground for mosquitoes. By February 1810, 60 officers and 3900 soldiers were reported dead.
It was recorded that from 1793 to 1815, the British recorded death due to malaria at about 240,000 and death due to wounds was less than 30,000. This would tell you that in the history of the world and wars fought, malaria took more soldiers that the war itself did. At a time the cost of purchasing anti-malaria drugs was higher the expense of the war itself.